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AXL 抗体 (Extracellular)

Name: AXL 抗体 (Extracellular)
SKU: ABIN7581829
Availability: OutOfStock

This anti-AXL antibody is a 兔多克隆 antibody detecting AXL in WB, IHC, FACS 和 LCI. Suitable for 人.

产品编号 ABIN7581829

发货至: 中国

Quick Overview for AXL 抗体 (Extracellular) (ABIN7581829)

抗原

See all AXL 抗体

AXL (AXL Receptor tyrosine Kinase (AXL))

适用

人

宿主

兔

克隆类型

多克隆

标记

This AXL antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Discover our top product AXL Primary Antibody

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AA 368-382, Extracellular

原理

A Rabbit Polyclonal antibody to AXL (extracellular)

序列

(C)RLAYQGQDTP EVLMD

特异性

Extracellular, N-term.

预测反应

Mouse,Rat - 14 out of 15 amino acids residues identical

产品特性

Anti-AXL (extracellular) Antibody (ABIN7581829) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize AXL from mouse, rat and human samples.

纯化方法

Affinity purified on immobilized antigen.

免疫原

(C)RLAYQGQDTPEVLMD, corresponding to amino acid residues 368 - 382 of human AXL

亚型

IgG
anti-AXL Receptor tyrosine Kinase (AXL) (AA 30-140) antibody
AXL 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 6C8 unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) antibody
AXL 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 13-44) antibody
AXL 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 151-250) antibody
AXL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 312-447) antibody
AXL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 21-202) antibody
AXL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 1-894) antibody
AXL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) antibody
AXL 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7E10 unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (C-Term) antibody
KO Validated AXL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-AXL Receptor tyrosine Kinase (AXL) (AA 787-885) antibody
AXL 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C10 unconjugated

应用备注

Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200

限制

仅限研究用
状态

Lyophilized

溶解方式

0.2 mL double distilled water (DDW).

浓度

1 mg/mL

缓冲液

PBS pH 7.4

储存条件

4 °C,-20 °C

储存方法

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
抗原

AXL (AXL Receptor tyrosine Kinase (AXL))

别名

AXL

背景

AXL Receptor Tyrosine Kinase, Tyrosine-Protein Kinase Receptor UFO, AXL Oncogene, Tyro7, UFO,AXL, also known as Tyrosine Kinase Receptor UFO and Tyro7, is a member of the receptor tyrosine kinase TAM family, that includes the receptors Tyro3, AXL and MERTK 1,2.The TAM family receptors are widely expressed in normal cells and tissues, such as monocytes, platelets, endothelial cells, brain and heart, where they regulate cell survival, non-inflammatory clearance of apoptotic cells by phagocytic cells, natural killer cell differentiation, platelet aggregation, and more 1,2.The TAM family receptors show structural similarities with other tyrosine kinase receptors, that is, an extracellular N-terminal domain containing two immunoglobulin-like and two fibronectin 3 domains, followed by a hydrophobic single pass transmembrane domain, and a cytoplasmic C-terminal tail containing a tyrosine kinase domain1,2.Axl and the other TAM receptors can be activated via their ligands, growth arrest specific 6 protein (Gas6) and Protein S (Pros1), which are members of the family of vitamin K-dependent proteins 3.Both AXL receptor and its high affinity ligand Gas6, are key regulators of immune cell activation, and have been shown to be expressed in cancer cells where they promote survival and invasion and contribute to resistance to various therapies 3,4,5. AXL expression is linked to increased risk of metastasis and poor survival in a variety of solid cancers including breast cancer, non-small cell lung carcinoma, ovarian cancer, and clear cell renal carcinoma 3,4. AXL activation in cancer cells and various stromal cells also results in tumor microenvironment deregulation, leading to modulation of angiogenesis, fibrosis, immune response and hypoxia 3,4.Based on these findings, AXL has been identified as a critical therapeutic target for solid cancers, and indeed several therapeutic modalities including small molecules and monoclonal antibodies, are currently being developed 2, 4.

基因ID

558

UniProt

P30530

途径

RTK signaling, Cellular Response to Molecule of Bacterial Origin