AXL 抗体 (AA 151-250)
(3 references)-
- 抗原 See all AXL 抗体
- AXL (AXL Receptor tyrosine Kinase (AXL))
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抗原表位
- AA 151-250
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AXL antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Dog,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human AXL
- 亚型
- IgG
- Top Product
- Discover our top product AXL Primary Antibody
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anti-AXL Receptor tyrosine Kinase (AXL) (AA 30-140) antibody
AXL 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 6C8 unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) antibodyAXL 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) antibodyAXL 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 13-44) antibodyAXL 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 312-447) antibodyAXL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 21-202) antibodyAXL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (AA 1-894) antibodyAXL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) antibodyAXL 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 7E10 unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) antibodyAXL 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 7-00E-10 unconjugated
anti-AXL Receptor tyrosine Kinase (AXL) (C-Term) antibodyKO Validated AXL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. ..." in: Communications biology, Vol. 4, Issue 1, pp. 1002, (2021) (PubMed).
: "Amlexanox, a selective inhibitor of IKBKE, generates anti-tumoral effects by disrupting the Hippo pathway in human glioblastoma cell lines." in: Cell death & disease, Vol. 8, Issue 8, pp. e3022, (2018) (PubMed).
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: "Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. ..." in: Communications biology, Vol. 4, Issue 1, pp. 1002, (2021) (PubMed).
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- 抗原
- AXL (AXL Receptor tyrosine Kinase (AXL))
- 别名
- AXL (AXL 产品)
- 别名
- JTK11 antibody, UFO antibody, AI323647 antibody, Ark antibody, Tyro7 antibody, Ufo antibody, AXL receptor tyrosine kinase antibody, Axl receptor tyrosine kinase antibody, AXL antibody, Axl antibody
- 背景
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Synonyms: UFO, JTK11, Tyrosine-protein kinase receptor UFO, AXL oncogene, AXL
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.
- 基因ID
- 558
- UniProt
- P30530
- 途径
- RTK signaling, Cellular Response to Molecule of Bacterial Origin
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