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AXL 抗体 (AA 312-447)

AXL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7174056
发货至: 中国
  • 抗原 See all AXL 抗体
    AXL (AXL Receptor tyrosine Kinase (AXL))
    抗原表位
    • 20
    • 20
    • 20
    • 16
    • 15
    • 12
    • 11
    • 9
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 312-447
    适用
    • 136
    • 62
    • 55
    • 6
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    宿主
    • 123
    • 19
    • 3
    • 1
    克隆类型
    • 123
    • 23
    多克隆
    标记
    • 59
    • 12
    • 11
    • 10
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This AXL antibody is un-conjugated
    应用范围
    • 118
    • 69
    • 37
    • 26
    • 26
    • 21
    • 15
    • 9
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Tyrosine-protein kinase receptor UFO protein (312-447AA)
    亚型
    IgG
    Top Product
    Discover our top product AXL Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    AXL (AXL Receptor tyrosine Kinase (AXL))
    别名
    AXL (AXL 产品)
    别名
    JTK11 antibody, UFO antibody, AI323647 antibody, Ark antibody, Tyro7 antibody, Ufo antibody, AXL receptor tyrosine kinase antibody, Axl receptor tyrosine kinase antibody, AXL antibody, Axl antibody
    背景

    Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

    Aliases: Adhesion related kinase antibody, AI323647 antibody, Ark antibody, Axl antibody, AXL oncogene antibody, AXL receptor tyrosine kinase antibody, AXL transforming gene antibody, AXL transforming sequence/gene antibody, EC 2.7.10.1 antibody, JTK11 antibody, Oncogene AXL antibody, Tyro7 antibody, Tyrosine protein kinase receptor UFO antibody, Tyrosine-protein kinase receptor UFO antibody, UFO antibody, UFO_HUMAN antibody

    UniProt
    P30530
    途径
    RTK signaling, Cellular Response to Molecule of Bacterial Origin
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