TIMELESS 抗体 (C-Term)
Quick Overview for TIMELESS 抗体 (C-Term) (ABIN7469068)
抗原
See all TIMELESS 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
交叉反应
- 人, 小鼠
-
纯化方法
- Purified by antigen-affinity chromatography.
-
免疫原
- Recombinant protein encompassing a sequence within the C-terminus region of human TIMELESS. The exact sequence is proprietary.
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:2000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
-
说明
-
Positive Control: 293T , A431 , HeLa , HepG2 , Neuro2A , C8D30 , NIH-3T3 , Raw 264.7 , C2Cl2
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
-
-
- TIMELESS (Timeless Homolog (TIMELESS))
-
别名
- timeless circadian regulator
-
背景
-
Synonyms: timeless circadian regulator , TIM , TIM1 , hTIM
Background: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
-
分子量
- 139 kDa
-
基因ID
- 8914
-
UniProt
- Q9UNS1
-
途径
- Protein targeting to Nucleus, Photoperiodism
抗原
-