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NFKBIB 抗体

This anti-NFKBIB antibody is a 兔 多克隆 antibody detecting NFKBIB in IF 和 ICC. Suitable for 人.
产品编号 ABIN7468657
发货至: 中国

Quick Overview for NFKBIB 抗体 (ABIN7468657)

抗原

See all NFKBIB 抗体
NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

适用

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宿主

  • 98
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克隆类型

  • 90
  • 18
多克隆

标记

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This NFKBIB antibody is un-conjugated

应用范围

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Immunofluorescence (IF), Immunocytochemistry (ICC)
  • 交叉反应

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human IKB beta. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

    别名

    NFKB inhibitor beta

    背景

    Synonyms: NFKB inhibitor beta , IKBB , TRIP9

    Background: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]

    分子量

    38 kDa

    基因ID

    4793

    UniProt

    Q15653

    途径

    NF-kappaB Signaling, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades
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