ATR 抗体 (pThr1989)
Quick Overview for ATR 抗体 (pThr1989) (ABIN7467984)
抗原
See all ATR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pThr1989
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交叉反应
- 人
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纯化方法
- Affinity purified by Protein A.
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免疫原
- Carrier-protein conjugated synthetic peptide surrounding phospho Thr1989 of human ATR. The exact sequence is proprietary.
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亚型
- IgG2b
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anti-Ataxia Telangiectasia and Rad3 Related (ATR) (AA 2353-2644) antibody
ATR 适用: 人 WB, IP, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia and Rad3 Related (ATR) (Ser428) antibodyATR 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ataxia Telangiectasia and Rad3 Related (ATR) (Internal Region) antibodyATR 适用: 人, 小鼠, 犬, 鱼, 猴, 大鼠, 非洲爪蟾 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: HCT116 , HCT116(100 J/m2 UVC and recover for 6hr) Validation: Orthogonal
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
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别名
- ATR serine/threonine kinase
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背景
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Synonyms: ATR serine/threonine kinase , FCTCS , FRP1 , MEC1 , SCKL , SCKL1
Background: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]
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分子量
- 301 kDa
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基因ID
- 545
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UniProt
- Q13535
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途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
抗原
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