TBP 抗体 (N-Term)
Quick Overview for TBP 抗体 (N-Term) (ABIN7465077)
抗原
See all TBP 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
 - N-Term
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交叉反应
 - 人
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纯化方法
 - Affinity purified by Protein G.
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免疫原
 - Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human TBP. The exact sequence is proprietary.
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亚型
 - IgG1
 
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应用备注
 - WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: 293T
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 mg/mL
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缓冲液
 - PBS, No Preservative
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储存液
 - Without preservative
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
 
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- TBP (TATA Box Binding Protein (TBP))
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别名
 - TATA-box binding protein
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背景
 - TATA-box binding protein , GTF2D , GTF2D1 , HDL4 , SCA17 , TFIID,Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. [provided by RefSeq]
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分子量
 - 38 kDa
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基因ID
 - 6908
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UniProt
 - P20226
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途径
 - WNT signaling
 
抗原
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