TP53BP1 抗体 (C-Term)
Quick Overview for TP53BP1 抗体 (C-Term) (ABIN7464819)
抗原
See all TP53BP1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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抗原表位
- C-Term
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Synthetic peptide corresponding to the carboxy-terminus of h53BP1, conjugated to a carrier protein.
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亚型
- IgG
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应用备注
- Suggested starting dilutions are as follows: WB: 1:500-1:3000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
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说明
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Positive Control: Neuro 2A , C8D30 , NIH-3T3 , HeLa
Validation: KO/KD
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.83 mg/mL
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缓冲液
- PBS, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
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别名
- tumor protein p53 binding protein 1
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背景
- Tumor protein p53 binding protein 1 , 53BP1 , TDRD30 , p202 , p53BP1,P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.
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分子量
- 214 kDa
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基因ID
- 7158
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UniProt
- Q12888
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途径
- DNA Damage Repair
抗原
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