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BMPR1B 抗体 (AA 61-160) (HRP)

BMPR1B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN719255
发货至: 中国
  • 抗原 See all BMPR1B 抗体
    BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))
    抗原表位
    • 12
    • 12
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
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    • 2
    • 2
    • 1
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    AA 61-160
    适用
    • 113
    • 43
    • 21
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 102
    • 11
    克隆类型
    • 104
    • 9
    多克隆
    标记
    • 46
    • 11
    • 11
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    • 1
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    • 1
    • 1
    • 1
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    This BMPR1B antibody is conjugated to HRP
    应用范围
    • 99
    • 70
    • 32
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    预测反应
    Human,Mouse,Rat,Dog,Cow,Sheep,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human BMPR1B
    亚型
    IgG
    Top Product
    Discover our top product BMPR1B Primary Antibody
  • 应用备注
    WB 1:300-5000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    注意事项
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    BMPR1B (Bone Morphogenetic Protein Receptor, Type IB (BMPR1B))
    别名
    BMPR1B (BMPR1B 产品)
    别名
    ALK6 antibody, BMPR-IB antibody, FecB antibody, alk-6 antibody, alk6 antibody, cdw293 antibody, alk6b antibody, zgc:172219 antibody, BMPR1B antibody, AI385617 antibody, ALK-6 antibody, AV355320 antibody, Acvrlk6 antibody, Alk6 antibody, BMPR-1B antibody, CFK-43a antibody, SKR6 antibody, BR1b antibody, alk6tr antibody, bmpr1b antibody, zALK-6 antibody, zgc:92220 antibody, CDw293 antibody, BMP15 antibody, BMPRIB antibody, RPK-1 antibody, bone morphogenetic protein receptor type 1B antibody, bone morphogenetic protein receptor, type IBb antibody, bone morphogenetic protein receptor, type 1B antibody, bone morphogenetic protein receptor, type IBa antibody, BMPR1B antibody, bmpr1b antibody, bmpr1bb antibody, Bmpr1b antibody, bmpr1ba antibody
    背景

    Synonyms: BMPR-IB, Activin receptor like kinase 6, Acvrlk6, ALK 6, ALK6, alk6tr, BMP type-1B receptor, BMPR IB, BMPR-1B, Bmpr1b, BMPRIB, BMR1B_HUMAN, Bone morphogenetic protein receptor type 1B, Bone morphogenetic protein receptor type IB, Bone morphogenetic protein receptor type-1B, BR 1b, BR1b, CDw 293, CDw293, CDw293 antigen, CFK 43a, CFK43a, Serine/threonine receptor kinase, zALK 6, zALK6.

    Background: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.Involvement in disease, Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA). Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers).Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo.

    基因ID
    658
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