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XPO1 抗体 (C-Term)

This anti-XPO1 antibody is a 兔 多克隆 antibody detecting XPO1 in WB, IP 和 IHC (fp). Suitable for 人 和 小鼠.
产品编号 ABIN7453427
发货至: 中国

Quick Overview for XPO1 抗体 (C-Term) (ABIN7453427)

抗原

See all XPO1 抗体
XPO1 (Exportin 1 (XPO1))

适用

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人, 小鼠

宿主

  • 73
  • 6
  • 1

克隆类型

  • 62
  • 18
多克隆

标记

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This XPO1 antibody is un-conjugated

应用范围

  • 51
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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 抗原表位

    • 15
    • 10
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    C-Term

    原理

    Rabbit anti-CRM1 Antibody, Affinity Purified

    纯化方法

    Affinity Purified

    免疫原

    between AA 1025 and C-term

    亚型

    IgG
  • 应用备注

    IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: 2 - 10 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    XPO1 (Exportin 1 (XPO1))

    别名

    CRM1

    背景

    Background: Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.

    基因ID

    7514

    NCBI登录号

    NP_003391

    UniProt

    O14980

    途径

    M Phase
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