TP53BP1 抗体 (pSer25)
Quick Overview for TP53BP1 抗体 (pSer25) (ABIN7453403)
抗原
See all TP53BP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer25
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原理
- Rabbit anti-Phospho 53BP1 (S25) Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- surrounding serine 25
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亚型
- IgG
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应用备注
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 1 - 4 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
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别名
- 53BP1
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背景
- Background: 53BP1 (p53 Binding Protein 1) is an early participant in the cellular response to DNA double-strand breaks. 53BP1 functions in a redundant role in phosphorylation of the downstream checkpoint effector proteins Brca1 and Chk2 but was required for the formation of Brca1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage.
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基因ID
- 7158
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NCBI登录号
- NP_005648
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UniProt
- Q12888
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途径
- DNA Damage Repair
抗原
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