MAP2K4 抗体 (AA 349-399)
Quick Overview for MAP2K4 抗体 (AA 349-399) (ABIN7451876)
抗原
See all MAP2K4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 349-399
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原理
- Rabbit anti-MKK4 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 349 and 399
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亚型
- IgG
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应用备注
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))
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别名
- MKK4
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背景
- Background: MAPKK4 (mitogen-activated protein kinase kinase 4) is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. MAPKK4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. Studies in knockout mice suggest that MAPKK4 mediates survival signals in T cell development. It may also be important to liver organogenesis.[taken from NCBI Entrez Gene (GeneID: 6416)].
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基因ID
- 6416
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NCBI登录号
- NP_003001
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UniProt
- P45985
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途径
- MAPK Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
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