FAS 抗体 (AA 285-335)
Quick Overview for FAS 抗体 (AA 285-335) (ABIN7451780)
抗原
See all FAS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 285-335
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原理
- Rabbit anti-FAS Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 285 and 335
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亚型
- IgG
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应用备注
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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别名
- FAS
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背景
- Background: Tumor necrosis factor receptor superfamily member 6, FAS, functions as the receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated FAS receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) which mediate apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both [taken from the Universal Protein Resource (UniProt) P25445].
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基因ID
- 355
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NCBI登录号
- NP_000034
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UniProt
- P25445
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途径
- p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
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