TRAF2 抗体 (AA 175-225)
Quick Overview for TRAF2 抗体 (AA 175-225) (ABIN7450839)
抗原
See all TRAF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 175-225
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原理
- Rabbit anti-TRAF2 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 175 and 225
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亚型
- IgG
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应用备注
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IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
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别名
- TRAF2
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背景
- Background: TNF receptor-associated factor 2 (TRAF2) regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. TRAF2 has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. TRAF2 is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases [taken from the Universal Protein Resource (UniProt) Q12933].
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基因ID
- 7186
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NCBI登录号
- NP_066961
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UniProt
- Q12933
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途径
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins
抗原
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