CPSF100 antibody, 100kDa antibody, 2610024B04Rik antibody, AI662483 antibody, Cpsf antibody, MCPSF antibody, mKIAA1367 antibody, zgc:92484 antibody, cpsf2-A antibody, cleavage and polyadenylation specific factor 2 antibody, cleavage and polyadenylation specific factor 2 S homeolog antibody, cleavage and polyadenylation specificity factor subunit 2 antibody, CPSF2 antibody, Cpsf2 antibody, cpsf2 antibody, PAAG_07931 antibody, cpsf2.S antibody, LOC582050 antibody, LOC100157277 antibody, LOC100179344 antibody
背景
Background: CPSF100/CPSF2 (cleavage and polyadenylation specific factor 2, 100 kDa subunit) is a subunit of the cleavage and polyadenylation specificity factor (CPSF) involved in mammalian mRNA 3'-end processing. CPSF, along with CstF (cleavage and stimulation factor), is critical for the recognition of cis-acting sequence elements on the pre-mRNA that dictate the site of cleavage and subsequent polyadenylation. CPSF exists as a complex of four proteins that includes CPSF160/CPSF1, CPSF100/CPSF2, CPSF73/CPSF3, and CPSF30/CPSF4. CPSF100/CPSF2 and CPSF73/CPSF3 are both members of the metallo-beta-lactamase superfamily of zinc-dependent hydrolases.