JNK 抗体
Quick Overview for JNK 抗体 (ABIN7384333)
抗原
See all JNK (MAPK8) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Affinity Purified
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亚型
- IgG
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应用备注
- WB 1:500-1:1000
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限制
- 仅限研究用
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浓度
- 300 μg/mL
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缓冲液
- 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
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别名
- JNK
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背景
- AI849689,c Jun N terminal kinase 1,C-JUN kinase 1,c-Jun N-terminal kinase 1,EC 2.7.11.24,JNK 1,JNK,JNK-46,JNK1A2,JNK21B1/2,MAP kinase 8,MAPK 8,mapk8,Mitogen activated protein kinase 8,Mitogen-activated protein kinase 8,MK08,p54 gamma,Prkm8,Protein kinase JNK1,Protein kinase,mitogen-activated,8,SAPK 1,SAPK gamma,SAPK1,Stress-activated protein kinase 1,Stress-activated protein kinase JNK1,MAPK8(Mitogen-activated protein kinase 8) is also named as JNK1,PRKM8,SAPK1,SAPK1C and belongs to the MAP kinase subfamily. MAPK8 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. MAPK8 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73,mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. It has 4 isoforms produced by alternative splicing with the molecular weight of 46 kDa and 48 kDa. This protein can be phosphorylated and this antibody recognizes the 46 kDa and 55 kDa bands in western blot.
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分子量
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Observed_MW: 46/54kDa
Calculated_MW: 48/53 kDa
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基因ID
- 5599
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UniProt
- P45983
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途径
- MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteins
抗原
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