This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],E3KARP,NHE3RF2,NHERF-2,NHERF2,OCTS2,SIP-1,SIP1,TKA-1,SLC9A3R2,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Endocrine & Metabolism,SLC9A3R2