SRPK2 抗体 (AA 420-520)
Quick Overview for SRPK2 抗体 (AA 420-520) (ABIN7270269)
抗原
See all SRPK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 420-520
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原理
- SRPK2 Rabbit pAb
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序列
- NAESDYTYSS SYEQFNGELP NGRHKIPESQ FPEFSTSLFS GSLEPVACGS VLSEGSPLTE QEESSPSHDR SRTVSASSTG DLPKAKTRAA DLLVNPLDPR N
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 420-520 of human SRPK2 (NP_872633.1).
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亚型
- IgG
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anti-SFRS Protein Kinase 2 (SRPK2) (AA 471-688) antibody
SRPK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SFRS Protein Kinase 2 (SRPK2) (AA 1-699) antibodySRPK2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-SFRS Protein Kinase 2 (SRPK2) antibodySRPK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SFRS Protein Kinase 2 (SRPK2) (AA 380-617) antibodySRPK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SFRS Protein Kinase 2 (SRPK2) (AA 465-495), (C-Term) antibodySRPK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB3353 unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SRPK2 (SFRS Protein Kinase 2 (SRPK2))
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别名
- SRPK2
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背景
- Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1 expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1 expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription, R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. Can mediate hepatitis B virus (HBV core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA without affecting the formation of the viral core particles.,SFRSK2,SRPK2,Epigenetics & Nuclear Signaling,RNA Binding,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Cyclins,SRPK2
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基因ID
- 6733
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UniProt
- P78362
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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