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OMA1 抗体 (AA 360-524)

OMA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7269095
发货至: 中国
  • 抗原 See all OMA1 抗体
    OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))
    抗原表位
    • 15
    • 5
    • 1
    • 1
    AA 360-524
    适用
    • 22
    • 17
    • 17
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    宿主
    • 22
    克隆类型
    • 22
    多克隆
    标记
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This OMA1 antibody is un-conjugated
    应用范围
    • 18
    • 13
    • 13
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    原理
    OMA1 Rabbit pAb
    序列
    AICPRDSLAL LCQWIQSKLQ EYMFNRPYSR KLEAEADKIG LLLAAKACAD IRASSVFWQQ MEFVDSLHGQ PKMPEWLSTH PSHGNRVEYL DRLIPQALKI REMCNCPPLS NPDPRLLFKL STKHFLEESE KEDLNITKKQ KMDTLPIQKQ EQIPLTYIVE KRTGS
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 360-524 of human OMA1 (NP_660286.1).
    亚型
    IgG
    Top Product
    Discover our top product OMA1 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:100
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    OMA1 (OMA1 Zinc Metallopeptidase Homolog (OMA1))
    别名
    OMA1 (OMA1 产品)
    别名
    2010001O09Rik antibody, DAB1 antibody, MPRP-1 antibody, YKR087C antibody, ZMPOMA1 antibody, peptidase antibody, RGD1304821 antibody, oma1 antibody, OMA1 zinc metallopeptidase antibody, si:ch73-215a11.1 antibody, olfactory receptor 4K2 antibody, OMA1 antibody, Oma1 antibody, si:ch73-215a11.1 antibody, LOC531304 antibody
    背景
    Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR: in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1, which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity. Binds cardiolipin, possibly regulating its protein turnover (By similarity. Required for the stability of the respiratory supercomplexes (By similarity.,OMA1,2010001O09Rik,DAB1,MPRP-1,MPRP1,YKR087C,ZMPOMA1,peptidase,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,OMA1
    分子量
    60kDa/55kDa
    基因ID
    115209
    UniProt
    Q96E52
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