This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],AQDQ, CI-18, CI-18 kDa, CI-AQDQ,Cancer,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial markers,Mitochondrial metabolism_Oxidative phosphorylation,Neurodegenerative Diseases,Neuroscience,Signal Transduction,NDUFS4