Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3) 抗体
HIVEP3
适用: 小鼠
IHC, WB
宿主: 兔
Polyclonal
unconjugated
-
- 抗原 See all Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3) products
- Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3)
-
适用
- 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- 非结合性
- 应用范围
- Immunohistochemistry (IHC), Western Blotting (WB)
- 原理
- Hivep3 Rabbit pAb
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of Mouse Hivep3.
- 亚型
- IgG
-
-
- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
- 抗原
- Human Immunodeficiency Virus Type I Enhancer Binding Protein 3 (HIVEP3)
- 别名
- Hivep3 (HIVEP3 产品)
- 别名
- 2900056N03Rik antibody, A130075N07 antibody, AI848000 antibody, E030045D18Rik antibody, KBP-1 antibody, KBP1 antibody, Krc antibody, Rc antibody, Schnurri-3 antibody, Shn3 antibody, Zas3 antibody, KRC antibody, SHN3 antibody, ZAS3 antibody, ZNF40C antibody, human immunodeficiency virus type I enhancer binding protein 3 antibody, human immunodeficiency virus type I enhancer binding protein 3 L homeolog antibody, transcription factor HIVEP3 antibody, HIVEP3 antibody, hivep3.L antibody, LOC100409919 antibody, hivep3 antibody, Hivep3 antibody
- 背景
- Plays a role of transcription factor, binds to recognition signal sequences (Rss heptamer for somatic recombination of immunoglobulin and T-cell receptor gene segments, Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation, Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus, through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.,Kr, Rc, Sh, Krc, KBP1, Shn3, Zas3, KBP-1, Schnu, AI848000, A130075N07, Schnurri-3, 2900056N03Rik, E030045D18Rik,Hivep3
- 分子量
- 253kDa
- 基因ID
- 16656
- UniProt
- A2A884
-
You are here:
