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EXOSC7 抗体

This anti-EXOSC7 antibody is a 兔 单克隆 antibody detecting EXOSC7 in WB 和 IHC. Suitable for 人.
产品编号 ABIN7267064
发货至: 中国

Quick Overview for EXOSC7 抗体 (ABIN7267064)

抗原

See all EXOSC7 抗体
EXOSC7 (Exosome Component 7 (EXOSC7))

适用

  • 33
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  • 1

宿主

  • 25
  • 8

克隆类型

  • 25
  • 8
单克隆

标记

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  • 1
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This EXOSC7 antibody is un-conjugated

应用范围

  • 16
  • 13
  • 13
  • 9
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  • 5
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  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • 原理

    EXOSC7 Rabbit mAb

    交叉反应

    产品特性

    Monoclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    A synthesized peptide derived from human EXOSC7.

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000,IHC,1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    EXOSC7 (Exosome Component 7 (EXOSC7))

    别名

    EXOSC7

    背景

    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR and/or Ig variable region somatic hypermutation (SHM by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9 is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.,EXOSC7, EAP1, RRP42, Rrp42p, hRrp42p, p8, exosome component 7,Epigenetics & Nuclear Signaling,EXOSC7

    分子量

    32kDa

    基因ID

    23016

    UniProt

    Q15024
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