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- 抗原 See all ARIH1 抗体
- ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))
- 抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ARIH1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- ARIH1 Rabbit pAb
- 序列
- ARDAQERSRA ALQRYLFYCN RYMNHMQSLR FEHKLYAQVK QKMEEMQQHN MSWIEVQFLK KAVDVLCQCR ATLMYTYVFA FYLKKNNQSI IFENNQADLE NATEVLSGYL ERDISQDSLQ DIKQKVQDKY RYCESRRRVL LQHVHEGYEK DLWEYIED
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of human ARIH1 (NP_005735.2).
- 亚型
- IgG
- Top Product
- Discover our top product ARIH1 Primary Antibody
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anti-Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1) (C-Term) antibody
Verified ARIH1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1) antibodyARIH1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1) (C-Term) antibodyARIH1 适用: 人, 小鼠, Cow, 犬, 斑马鱼, 豚鼠, 马, 兔, 大鼠, 猴, Bat, Pig, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1) (C-Term) antibodyARIH1 适用: 人, 小鼠, Cow, 犬, 斑马鱼, 豚鼠, 马, 兔, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1) antibodyARIH1 适用: 人, 小鼠, 犬, 斑马鱼 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))
- 别名
- ARIH1 (ARIH1 产品)
- 别名
- ARIH1 antibody, ARI-1 antibody, ari antibody, ariadne antibody, hari antibody, hhari antibody, ubch7bp antibody, ARI antibody, HARI antibody, HHARI antibody, UBCH7BP antibody, AU021774 antibody, Ari antibody, Ari1 antibody, Hari antibody, Hhari antibody, Ubch7bp antibody, Uip77 antibody, wu:fa18d01 antibody, zgc:66364 antibody, ariadne RBR E3 ubiquitin protein ligase 1 antibody, ariadne RBR E3 ubiquitin protein ligase 1 L homeolog antibody, ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) antibody, Arih1 antibody, ARIH1 antibody, arih1 antibody, arih1.L antibody
- 背景
- E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology.,ARIH1,ARI,HARI,HHARI,UBCH7BP,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Endocrine & Metabolism,Amino acid metabolism,ARIH1
- 基因ID
- 25820
- UniProt
- Q9Y4X5
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