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IGF1 抗体 (Secreted)

This 兔多克隆 antibody specifically detects IGF1 in WB 和 IHC. It exhibits reactivity toward 大鼠.

Expression of IGF1 in mouse hippocampus. (IGF1 抗体 (Secreted))

IHC

Expression of IGF1 in mouse parietal cortex. (IGF1 抗体 (Secreted))

IHC

3 images

产品编号 ABIN7237701

发货至: 中国

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Quick Overview for IGF1 抗体 (Secreted) (ABIN7237701)

抗原

See all IGF1 抗体

IGF1 (Insulin-Like Growth Factor 1 (IGF1))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This IGF1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product IGF1 Primary Antibody

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AA 74-85, Secreted

原理

A Rabbit Polyclonal antibody to IGF1

交叉反应

人, 小鼠, 大鼠

交叉反应（详细）

The antibody is specific for IGF1, it does not crossreact with IGF2.

预测反应

Mouse - identical, Human - 11 out of 12 amino acid residues identical

产品特性

Secreted

纯化方法

Affinity purified on immobilized antigen.

免疫原

(C)NKPTGYGSSIRR, corresponding to amino acid residues 74 - 85 of rat IGF1

亚型

IgG
anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-118) antibody
IGF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-118) antibody
IGF1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C10 unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-118) antibody
IGF1 适用: 人 WB, ICC, IF 宿主: 小鼠 Monoclonal C1 unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-153) antibody
IGF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (Internal Region) antibody
Verified IGF1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 115-144), (C-Term) antibody
IGF1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB33711 unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 115-144) antibody
IGF1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-100) antibody
IGF1 适用: 人, 小鼠, 大鼠, 犬 WB, IP, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 33-102) antibody
IGF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) antibody (Atto 488)
IGF1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal Atto 488

应用备注

WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user

说明

Negative Control: (ABIN7235814)
Blocking Peptide: (ABIN7235814)

限制

仅限研究用
状态

Lyophilized

溶解方式

25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

浓度

0.8 mg/mL

缓冲液

PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
抗原

IGF1 (Insulin-Like Growth Factor 1 (IGF1))

别名

IGF1

背景

Synonyms: Insulin Like Growth Factor 1, Insulin-Like Growth Factor I, IGF-I, Somatomedin-C
Description: IGF-1 originally called somatomedin C is a 70-amino acid hormone with homology to IGF-2 and proinsulin. IGF-1 acts as an endocrine, paracrine, and autocrine hormone and is known as a mediator of prenatal and postnatal growth. IGF-1 is mainly synthesized in the liver and regulated by growth hormones (GH) in peripheral tissues such as muscle, cartilage, bone, kidney, nerves, skin, lungs, and the liver itself. The synthesized IGF-1 binds to IGF-1 binding proteins (IGFBPs) with high affinity, IGFBPs regulates the interactions of IGF-1 and its receptor (IGF-1R)1. Binding of IGF-1 to his receptor results in autophosphorylation of the receptor leading to activation of the insulin receptor substrate 1 (IRS1) protein. The activated receptor contains several phosphotyrosine sites that serve as docking sites for many signaling proteins. The association of these proteins together start a complex signaling pathway including the canonical PI3-kinase and mitogen-activated protein (MAP) kinase pathways2.The IGF-1 signaling pathway is a major regulator of the aging process, from rodents to humans3. IGF-1 deficiency follows an autosomal mode of transmission and different mutations can lead to either IGF-1 deletion or low levels of circulation IGF-1. Studies demonstrate IGF-1 deficit can lead to deregulated lipid metabolism, cardiovascular disease (CVD), diabetes, and altered metabolic profile of diabetic patients4.

基因ID

24482

NCBI登录号

NM_000618

UniProt

P08025

途径

RTK signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation