LEF1 抗体 (pSer42)
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Quick Overview for LEF1 抗体 (pSer42) (ABIN7222980)
抗原
See all LEF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer42
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原理
- LEF-1 (phospho Ser42) Polyclonal Antibody
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特异性
- Phospho-LEF-1 (S42) Polyclonal Antibody detects endogenous levels of LEF-1 protein only when phosphorylated at S42.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human LEF-1 Phospho-Ser42
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))
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别名
- LEF-1
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背景
- Rabbit Anti-LEF-1 (phospho Ser42) Polyclonal Antibody,LEF1, Lymphoid enhancer-binding factor 1, LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha,LEF1 (lymphoid enhancer binding factor 1) encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in LEF1 have been found in somatic sebaceous tumors. LEF1 has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.,Lymphoid enhancer-binding factor 1
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分子量
- observerd band 55kDa
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基因ID
- 51176
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UniProt
- Q9UJU2
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途径
- WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding
抗原
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