BAI1 抗体 (AA 670-750)
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Quick Overview for BAI1 抗体 (AA 670-750) (ABIN7223780)
抗原
See all BAI1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 670-750
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原理
- BAI-1 Polyclonal Antibody
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特异性
- BAI-1 Polyclonal Antibody detects endogenous levels of BAI-1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human BAI-1 at AA range: 670-750
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- BAI1 (Brain-Specific Angiogenesis Inhibitor 1 (BAI1))
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别名
- BAI-1
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背景
- Rabbit Anti-BAI-1 Polyclonal Antibody,BAI1, Brain-specific angiogenesis inhibitor 1,Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 (adhesion G protein-coupled receptor B1, ADGRB1) contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.,Brain-specific angiogenesis inhibitor 1
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基因ID
- 575
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UniProt
- O14514
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途径
- p53 Pathway
抗原
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