VP35 (AA 1-329) 抗体 (Biotin)
适用: Reston Ebola virus
ELISA
宿主: 兔
Polyclonal
Biotin
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- 抗原
- VP35
- 抗原表位
- AA 1-329
- 适用
- Reston Ebola virus
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- Biotin
- 应用范围
- ELISA
- 交叉反应
- Reston Ebola virus
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)
- 亚型
- IgG
-
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- 抗原
- VP35
- 背景
-
Background: Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.
Aliases: VP35 antibody, Polymerase cofactor VP35 antibody
- UniProt
- Q91DE0
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