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ISG15 抗体 (AA 2-157) (Biotin)

This anti-ISG15 antibody is a 兔 多克隆 antibody detecting ISG15 in ELISA. Suitable for 人.
产品编号 ABIN7174559
发货至: 中国

Quick Overview for ISG15 抗体 (AA 2-157) (Biotin) (ABIN7174559)

抗原

See all ISG15 抗体
ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

适用

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宿主

  • 56
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克隆类型

  • 49
  • 15
多克隆

标记

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This ISG15 antibody is conjugated to Biotin

应用范围

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ELISA
  • 抗原表位

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    AA 2-157

    交叉反应

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Ubiquitin-like protein ISG15 protein (2-157AA)

    亚型

    IgG
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))

    别名

    ISG15

    背景

    Background: Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections. Ref.12 Ref.13 Ref.14 Ref.15 Ref.20 Ref.21In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy

    Aliases: G1P2 antibody, hUCRP antibody, IFI 15 antibody, IFI15 antibody, Interferon alpha inducible protein antibody, Interferon induced protein 15 antibody, Interferon induced protein IFI-15K antibody, Interferon stimulated protein 15 kDa antibody, Interferon, alpha-inducible protein (clone IFI-15K) antibody, Interferon-induced 15 kDa protein antibody, Interferon-induced 17 kDa protein antibody, Interferon-induced 17- kDa/15- kDa protein antibody, IP17 antibody, ISG 15 antibody, ISG15 antibody, ISG15 ubiquitin like modifier antibody, ISG15_HUMAN antibody, Ubiquitin cross-reactive protein antibody, Ubiquitin-like protein ISG15 antibody, UCRP antibody

    UniProt

    P05161
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