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ISG15 抗体 (AA 31-61)

ISG15 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3031502
发货至: 中国
  • 抗原 See all ISG15 抗体
    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
    抗原表位
    • 10
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 31-61
    适用
    • 60
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    宿主
    • 55
    • 6
    • 1
    克隆类型
    • 53
    • 9
    多克隆
    标记
    • 39
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ISG15 antibody is un-conjugated
    应用范围
    • 48
    • 30
    • 26
    • 11
    • 7
    • 5
    • 5
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    纯化方法
    Antigen affinity purified
    免疫原
    A portion of amino acids 31-61 from the human protein was used as the immunogen for this ISG15 antibody.
    亚型
    Ig Fraction
    Top Product
    Discover our top product ISG15 Primary Antibody
  • 应用备注
    Titration of the ISG15 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100,Western blot: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the ISG15 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    ISG15 (ISG15 Ubiquitin-Like Modifier (ISG15))
    别名
    ISG15 (ISG15 产品)
    别名
    G1P2 antibody, IFI15 antibody, IP17 antibody, UCRP antibody, hUCRP antibody, ISG15 antibody, g1p2 antibody, si:rp71-1c23.2 antibody, G1p2 antibody, IGI15 antibody, Irfp antibody, ISG17 antibody, ISG17/UCRP antibody, ISG15 ubiquitin-like modifier antibody, ISG15 antibody, isg15 antibody, Isg15 antibody
    背景
    ISG15 is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MCH (major histocompatibility complex)-restricted cytotoxicity. Synthesis is stimulated by IFN-alpha or IFN-beta or IFN-omega , but not IFN-gamma . ISG15 expression is also induced by overexpression of interferon regulatory factors that participate in transcriptional regulation of IFN genes, and by influenza B virus. ISG15 is secreted also by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins. The induction of terminal differentiation in human melanoma cells is associated with alterations in ISG15 expression. Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may be responsible for amplifying and directing some of the immunomodulatory effects of IFN-alpha or IFN-beta. ISG15 has has also been shown to function intracellularly as a ubiquitin homolog.
    UniProt
    P05161
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