SMARCE1 抗体 (AA 20-243)
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- 抗原 See all SMARCE1 抗体
- SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))
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抗原表位
- AA 20-243
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMARCE1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 protein (20-243AA)
- 亚型
- IgG
- Top Product
- Discover our top product SMARCE1 Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))
- 别名
- SMARCE1 (SMARCE1 产品)
- 别名
- BAF57 antibody, XBaf57 antibody, MGC52696 antibody, MGC69429 antibody, MGC81726 antibody, SMARCE1 antibody, DKFZp459O2235 antibody, fb54d11 antibody, wu:fb33d02 antibody, wu:fb54d11 antibody, Baf57 antibody, 2810417B20Rik antibody, 5830412H02Rik antibody, 9030408N19Rik antibody, Baf27 antibody, RGD1304726 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 L homeolog antibody, smarce1 antibody, SMARCE1 antibody, smarce1.L antibody, Smarce1 antibody
- 背景
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Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
Aliases: BAF57 antibody, BRG1 associated factor 57 antibody, BRG1-associated factor 57 antibody, Chromatin remodeling complex BRG1 associated factor 57 antibody, FLJ35648 antibody, SMARCE 1 antibody, SMARCE1 antibody, SMCE1_HUMAN antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin e1 antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 antibody, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 antibody
- UniProt
- Q969G3
- 途径
- Chromatin Binding
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