LATS1 抗体 (AA 1-280)
Quick Overview for LATS1 抗体 (AA 1-280) (ABIN7169059)
抗原
See all LATS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-280
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA)
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亚型
- IgG
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anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 521-620) antibody
LATS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (Internal Region) antibodyLATS1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1079) antibodyLATS1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30), (N-Term) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB3029 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-1130) antibodyLATS1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 971-1020) antibodyLATS1 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, 兔, Cow, 斑马鱼, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (Middle Region) antibodyLATS1 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 斑马鱼, Saccharomyces cerevisiae, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (N-Term) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IHC:1:100-1:1200, IF:1:50-1:500, IP:1:200-1:2000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
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别名
- LATS1
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背景
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Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Aliases: h-warts antibody, Large tumor suppressor homolog 1 antibody, LATS large tumor suppressor homolog 1 antibody, LATS1 antibody, LATS1_HUMAN antibody, Serine threonine protein kinase LATS1 antibody, Serine/threonine-protein kinase LATS1 antibody, WARTS antibody, WARTS protein kinase antibody, wts antibody
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UniProt
- O95835
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途径
- Regulation of Actin Filament Polymerization, Maintenance of Protein Location
抗原
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