PSME4 抗体 (AA 105-198)
Quick Overview for PSME4 抗体 (AA 105-198) (ABIN7164923)
抗原
See all PSME4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 105-198
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Proteasome activator complex subunit 4 protein (105-198AA)
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亚型
- IgG
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anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 1634-1843) antibody
PSME4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 503-535) antibodyPSME4 适用: 人 WB 宿主: 兔 Polyclonal RB55279 unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
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别名
- PSME4
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背景
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Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Aliases: KIAA0077 antibody, PA200 antibody, Proteasome Activator 200 kDa antibody, Proteasome activator complex subunit 4 antibody, Proteasome activator PA200 antibody, PSME 4 antibody, psme4 antibody, PSME4_HUMAN antibody
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UniProt
- Q14997
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途径
- DNA Replication, Synthesis of DNA
抗原
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