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- 抗原 See all PSME4 抗体
- PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
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抗原表位
- AA 503-535
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PSME4 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- B
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This PSME4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-535 amino acids from human PSME4.
- 克隆位点
- RB55279
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PSME4 Primary Antibody
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anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 105-198) antibody
PSME4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
- 别名
- PSME4 (PSME4 产品)
- 别名
- proteasome activating protein 200 antibody, Afu4g11290 antibody, An04g05320 antibody, AO090003001091 antibody, PA200 antibody, AA409398 antibody, AU041366 antibody, TEMO antibody, mKIAA0077 antibody, proteasome activator subunit 4 antibody, proteasome activating protein 200 antibody, proteasome (prosome, macropain) activator subunit 4 antibody, PSME4 antibody, Psme4 antibody, PA200 antibody, AFUA_4G11290 antibody, ANI_1_888184 antibody, AOR_1_1944154 antibody, TERG_07227 antibody, psme4 antibody
- 背景
- Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
- 分子量
- 211334
- UniProt
- Q14997
- 途径
- DNA Replication, Synthesis of DNA
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