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PCNA 抗体 (AA 1-261)

This anti-PCNA antibody is a 兔 多克隆 antibody detecting PCNA in WB, IHC, ELISA 和 IF. Suitable for 人.
产品编号 ABIN7164738
发货至: 中国

Quick Overview for PCNA 抗体 (AA 1-261) (ABIN7164738)

抗原

See all PCNA 抗体
PCNA (Proliferating Cell Nuclear Antigen (PCNA))

适用

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宿主

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克隆类型

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多克隆

标记

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This PCNA antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
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    AA 1-261

    交叉反应

    人, 小鼠

    纯化方法

    >95%, Protein G purified

    免疫原

    Recombinant Human Proliferating cell nuclear antigen protein (1-261AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: WB:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    PCNA (Proliferating Cell Nuclear Antigen (PCNA))

    别名

    PCNA

    背景

    Background: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\'s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3\'-5\' exonuclease and 3\'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while \'Lys-63\'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

    Aliases: ATLD2 antibody, cb16 antibody, Cyclin antibody, DNA polymerase delta auxiliary protein antibody, etID36690.10 antibody, fa28e03 antibody, fb36g03 antibody, HGCN8729 antibody, MGC8367 antibody, Mutagen-sensitive 209 protein antibody, OTTHUMP00000030189 antibody, OTTHUMP00000030190 antibody, PCNA antibody, Pcna/cyclin antibody, PCNA_HUMAN antibody, PCNAR antibody, Polymerase delta accessory protein antibody, Proliferating cell nuclear antigen antibody, wu:fa28e03 antibody, wu:fb36g03 antibody

    UniProt

    P12004

    途径

    Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
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