NPC1 抗体 (AA 23-269)
Quick Overview for NPC1 抗体 (AA 23-269) (ABIN7161727)
抗原
See all NPC1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 23-269
-
交叉反应
- 人
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human NPC intracellular cholesterol transporter 1 protein (23-269AA)
-
亚型
- IgG
-
-
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibody
NPC1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 8D10G3 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibodyNPC1 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 8D10B6 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 151-250) antibodyNPC1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4H2 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) antibodyNPC1 适用: 人 WB, IHC, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB33297 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (Internal Region) antibodyVerified NPC1 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (C-Term) antibodyNPC1 适用: 人, 小鼠, Hamster WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (C-Term) antibodyNPC1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
-
别名
- NPC1
-
背景
-
Background: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \\\'tag team duo\\\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.
Aliases: Niemann Pick C1 protein precursor antibody, Niemann Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC antibody, NPC1 antibody, NPC1_HUMAN antibody
-
UniProt
- O15118
抗原
-
