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GPR18 抗体 (AA 290-331) (FITC)

This FITC-conjugated 兔 多克隆 anti-GPR18 antibody specifically detects GPR18 in not_set. The antibody is reactive with 人 samples.
产品编号 ABIN7160751
发货至: 中国
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Quick Overview for GPR18 抗体 (AA 290-331) (FITC) (ABIN7160751)

抗原

See all GPR18 抗体
GPR18 (G Protein-Coupled Receptor 18 (GPR18))

适用

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宿主

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克隆类型

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多克隆

标记

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This GPR18 antibody is conjugated to FITC

应用范围

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  • 抗原表位

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    AA 290-331

    原理

    GPR18 Antibody, FITC conjugated

    纯化方法

    Protein G purified

    纯度

    >95 %

    免疫原

    Recombinant Human N-arachidonyl glycine receptor protein (290-331AA)

    亚型

    IgG
  • 限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    GPR18 (G Protein-Coupled Receptor 18 (GPR18))

    别名

    GPR18

    背景

    Background: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).

    Aliases: GPR18 antibody, GPCRWN-arachidonyl glycine receptor antibody, NAGly receptor antibody, G-protein coupled receptor 18 antibody

    UniProt

    Q14330
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