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TDG 抗体 (AA 141-410)

This anti-TDG antibody (ABIN7153379) is a Rabbit Polyclonal antibody detecting TDG in WB, ELISA, IHC. Suitable for Human.
产品编号 ABIN7153379
发货至: 中国

Quick Overview for TDG 抗体 (AA 141-410) (ABIN7153379)

抗原

See all TDG 抗体
TDG (Thymine-DNA Glycosylase (TDG))

适用

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宿主

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克隆类型

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多克隆

标记

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This TDG antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
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    AA 141-410

    交叉反应

    人, 小鼠

    纯化方法

    Antigen Affinity Purified

    免疫原

    Recombinant Human G/T mismatch-specific thymine DNA glycosylase protein (141-410AA)

    亚型

    IgG
  • 应用备注

    Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    TDG (Thymine-DNA Glycosylase (TDG))

    别名

    TDG

    背景

    Background: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

    Aliases: C JUN leucine zipper interactive protein antibody, C JUN leucine zipper interactive protein antibody, C-JUN leucine zipper interactive protein JZA-3 antibody, E130317C12Rik antibody, EC 3.2.2.29 antibody, G/T mismatch specific thymine DNA glycosylase antibody, G/T mismatch specific thymine DNA glycosylase antibody, G/T mismatch-specific thymine DNA glycosylase antibody, JZA 3 antibody, Jza1 antibody, T:G mismatch thymine glycosylase antibody, Tdg antibody, TDG_HUMAN antibody, Thymine DNA glycosylase antibody, Thymine-DNA glycosylase antibody

    UniProt

    Q13569

    途径

    DNA Damage Repair, Chromatin Binding
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