FBXW7 抗体 (AA 1-707) (Biotin)
Quick Overview for FBXW7 抗体 (AA 1-707) (Biotin) (ABIN7152510)
抗原
See all FBXW7 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-707
-
交叉反应
- 人
-
纯化方法
- >95%, Protein G purified
-
免疫原
- Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA)
-
亚型
- IgG
-
-
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) antibody
FBXW7 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 豚鼠, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 501-600) antibodyFBXW7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibodyFBXW7 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-627) antibodyFBXW7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 279-515) antibodyFBXW7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-707) antibodyFBXW7 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibodyFBXW7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) antibodyFBXW7 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 兔, 豚鼠, 马, 斑马鱼, Drosophila melanogaster, 猴, 非洲爪蟾, Hamster, Bat, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 251-300) antibodyFBXW7 适用: 小鼠, 大鼠, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-708) antibodyFBXW7 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
-
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
-
别名
- FBXW7
-
背景
-
Background: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463).
Aliases: AGO antibody, Archipelago antibody, Archipelago homolog antibody, Archipelago, Drosophila, homolog of antibody, CDC4 antibody, CDC4, S.cerevisiae, homolog of antibody, DKFZp686F23254 antibody, F box and WD 40 domain protein 7 (archipelago homolog, Drosophila) antibody, F box and WD 40 domain protein 7 antibody, F box and WD repeat domain containing 7 antibody, F box protein FBW7 antibody, F box protein FBX30 antibody, F box protein SEL 10 antibody, F box protein SEL10 antibody, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase antibody, F-box and WD-40 domain-containing protein 7 antibody, F-box protein FBX30 antibody, F-box/WD repeat-containing protein 7 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, FBXW7 antibody, FBXW7_HUMAN antibody, FLJ16457 antibody, hAgo antibody, hCdc4 antibody, Homolog of C elegans sel 10 antibody, Homolog of C.elegans sel10 antibody, SEL 10 antibody, SEL-10 antibody, SEL10 antibody
-
UniProt
- Q969H0
-
途径
- Notch Signaling, EGFR Signaling Pathway
抗原
-
