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Caspase 8 抗体 (AA 217-374)

Name: Caspase 8 抗体 (AA 217-374)
Brand: antibodies-online
SKU: ABIN7146964
Availability: OutOfStock

This anti-Caspase 8 antibody is a 兔多克隆 antibody detecting Caspase 8 in WB, IHC, ELISA 和 IF. Suitable for 人.

Western blot All lanes: CASP8 antibody at 2 μg/mL Lane 1: ACCM whole cell lysate Lane 2: LO2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 56, 54, 46, 58, 28, 26, 33, 31, 62 kDa Observed band size: 56 kDa (Caspase 8 抗体 (AA 217-374))

Immunohistochemistry of paraffin-embedded human kidney tissue using ABIN7146964 at dilution of 1:20 (Caspase 8 抗体 (AA 217-374))

IHC

Immunohistochemistry of paraffin-embedded human colon cancer using ABIN7146964 at dilution of 1:20 (Caspase 8 抗体 (AA 217-374))

IHC

Immunofluorescent analysis of HepG2 cells using ABIN7146964 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) (Caspase 8 抗体 (AA 217-374))

4 images

产品编号 ABIN7146964

发货至: 中国

Datasheet as PDF

Quick Overview for Caspase 8 抗体 (AA 217-374) (ABIN7146964)

抗原

See all Caspase 8 (CASP8) 抗体

Caspase 8 (CASP8)

适用

人

宿主

兔

克隆类型

多克隆

标记

This Caspase 8 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Discover our top product CASP8 Primary Antibody

抗原表位
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AA 217-374

交叉反应

人

纯化方法

>95%, Protein G purified

免疫原

Recombinant Human Caspase-8 protein (217-374AA)

亚型

IgG
anti-Caspase 8 (CASP8) (AA 411-482) antibody
CASP8 适用: 人, 小鼠, 大鼠, 猴, Pig, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 1-479) antibody
CASP8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 188-280) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 385-479) antibody
CASP8 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 217-384) antibody
CASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 7-201) antibody
CASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) antibody
CASP8 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1H11 unconjugated

anti-Caspase 8 (CASP8) (AA 410-449), (N-Term) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) antibody
CASP8 适用: 小鼠 WB, IHC, ELISA, ICC, FACS 宿主: 大鼠 Monoclonal 3B10 unconjugated

anti-Caspase 8 (CASP8) (pSer347) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended dilution: WB:1:500-1:2000, IHC:1:10-1:100, IF:1:50-1:200,

限制

仅限研究用
状态

Liquid

缓冲液

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

Caspase 8 (CASP8)

别名

CASP8

背景

Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Aliases: ALPS2B antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody, Apoptosis related cysteine peptidase antibody, Apoptotic cysteine protease antibody, Apoptotic protease Mch-5 antibody, Apoptotic protease Mch5 antibody, CAP 4 antibody, CAP4 antibody, CASP-8 antibody, CASP8 antibody, CASP8_HUMAN antibody, Caspase 8 antibody, Caspase 8 apoptosis related cysteine peptidase antibody, Caspase IIX antibody, Caspase-8 subunit p10 antibody, caspase8 antibody, CED 3 antibody, FADD Homologous ICE/CED3 Like Protease antibody, FADD Like ICE antibody, FADD-homologous ICE/CED-3-like protease antibody, FADD-like ICE antibody, FLICE antibody, FLJ17672 antibody, ICE-like apoptotic protease 5 antibody, MACH alpha 1/2/3 protein antibody, MACH antibody, MACH beta 1/2/3/4 protein antibody, MACH5 antibody, MCH 5 antibody, MCH5 antibody, MGC78473 antibody, MORT1 associated ced 3 homolog antibody, MORT1 associated CED3 homolog antibody, MORT1-associated CED-3 homolog antibody, OTTHUMP00000163717 antibody, OTTHUMP00000163720 antibody, OTTHUMP00000163724 antibody, OTTHUMP00000163725 antibody, OTTHUMP00000165062 antibody, OTTHUMP00000165063 antibody, OTTHUMP00000165064 antibody, OTTHUMP00000206552 antibody, OTTHUMP00000206582 antibody

UniProt

Q14790

途径

Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades