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- 抗原 See all AP2B1 抗体
- AP2B1 (Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1))
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抗原表位
- AA 738-937
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AP2B1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人, 小鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human AP-2 complex subunit beta protein (738-937AA)
- 亚型
- IgG
- Top Product
- Discover our top product AP2B1 Primary Antibody
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anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (AA 752-951) antibody
AP2B1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) antibodyAP2B1 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (AA 585-651) antibodyAP2B1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2D5 unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (AA 585-652) antibodyAP2B1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2D5 unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (Internal Region) antibodyAP2B1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (C-Term) antibodyAP2B1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (AA 497-546) antibodyAP2B1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, 小鸡, 猴, Pig, 非洲爪蟾, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (AA 651-700) antibodyAP2B1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (Middle Region) antibodyAP2B1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1) (C-Term) antibodyAP2B1 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- AP2B1 (Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1))
- 别名
- AP2B1 (AP2B1 产品)
- 别名
- 5-HT(2B) antibody, 5-HT2B antibody, ADTB2 antibody, AP105B antibody, AP2-BETA antibody, CLAPB1 antibody, 1300012O03Rik antibody, AI788979 antibody, fa16e07 antibody, wu:fa16c06 antibody, wu:fa16e07 antibody, wu:fc18c08 antibody, zgc:55659 antibody, 5-hydroxytryptamine receptor 2B antibody, adaptor related protein complex 2 beta 1 subunit antibody, adaptor-related protein complex 2, beta 1 subunit antibody, adaptor related protein complex 2 beta 1 subunit L homeolog antibody, HTR2B antibody, AP2B1 antibody, Ap2b1 antibody, ap2b1 antibody, ap2b1.L antibody
- 背景
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Background: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins, at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly, clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
Aliases: Adapter related protein complex 2 beta 1 subunit antibody, Adapter-related protein complex 2 beta subunit antibody, Adaptin, beta 2 (beta) antibody, Adaptor protein complex AP-2 subunit beta antibody, Adaptor related protein complex 2, beta 1 subunit antibody, ADTB2 antibody, AP-2 complex subunit beta antibody, AP105B antibody, AP2 BETA antibody, Ap2b1 antibody, AP2B1_HUMAN antibody, Beta adaptin antibody, Beta-2-adaptin antibody, Beta-adaptin antibody, Beta2 adaptin antibody, CLAPB1 antibody, Clathrin assembly protein complex 2 beta large chain antibody, Clathrin associated/assembly/adaptor protein, large, beta 1 antibody, DKFZp781K0743 antibody, Plasma membrane adaptor HA2/AP2 adaptin beta subunit antibody
- UniProt
- P63010
- 途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
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