RPA1 抗体
Quick Overview for RPA1 抗体 (ABIN7140348)
抗原
See all RPA1 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 猴, 小鼠, 大鼠
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纯化方法
- Affinity purified
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免疫原
- Purified recombinant human RPA70 protein fragments expressed in E.coli.
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亚型
- IgG2a
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应用备注
- Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200IP:1:200-1:2000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified mouse monoclonal antibody in PBS( pH 7.4) containing with 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RPA1 (Replication Protein A1, 70kDa (RPA1))
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别名
- RPA1
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背景
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Background: Plays an essential role in several cellular processes in DNA metabolism including replication,recombination and DNA repair.Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair,it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Aliases: Dmrpa1, Drosophila Replication Protein A, DRPA, HSSB, Human single stranded DNA binding protein, MST075, MSTP075, p70, REPA1, Replication factor A, Replication factor A protein 1, Replication protein A 70 kDa DNA-binding subunit,
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UniProt
- P27694
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途径
- Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
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