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- 抗原 See all LEO1 抗体
- LEO1 (Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1))
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抗原表位
- AA 2-24
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LEO1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Peptide sequence from Human RNA polymerase-associated protein LEO1 protein (2-24AA)
- 亚型
- IgG
- Top Product
- Discover our top product LEO1 Primary Antibody
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anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) antibody
LEO1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (pSer551) antibodyLEO1 适用: 人 WB, ELISA, DB 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (AA 451-550) antibodyLEO1 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) antibodyLEO1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (pSer10) antibodyLEO1 适用: 人 DB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (AA 550-600) antibodyLEO1 适用: 人 WB, IHC, IHC (p), IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (AA 616-650), (C-Term) antibodyLEO1 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB50947 unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (N-Term) antibodyLEO1 适用: 人, 大鼠, 小鼠, 犬, 马, 兔, 豚鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (N-Term) antibodyLEO1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1) (AA 130-159), (N-Term) antibodyLEO1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB10466 unconjugated
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- 应用备注
- Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- LEO1 (Leo1, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) (LEO1))
- 别名
- LEO1 (LEO1 产品)
- 别名
- LEO1 antibody, RDL antibody, Gm185 antibody, zgc:77374 antibody, LEO1 homolog, Paf1/RNA polymerase II complex component antibody, Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) antibody, RNA polymerase-associated protein LEO1 antibody, LEO1 homolog, Paf1/RNA polymerase II complex component S homeolog antibody, Leo1, Paf1/RNA polymerase II complex component antibody, LEO1 antibody, leo1 antibody, LOC100466503 antibody, leo1.S antibody, Leo1 antibody, LOC415420 antibody, LOC478310 antibody
- 背景
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Background: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and \'Ser-2\'- and \'Ser-5\'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 \'Lys-4\' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of \'Lys-120\' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3\' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
Aliases: Gm185 antibody, LEO1 antibody, LEO1_HUMAN antibody, LOC123439 antibody, Paf1/RNA polymerase II complex component antibody, Replicative senescence down regulated leo1 like protein antibody, Replicative senescence down-regulated leo1-like protein antibody, Replicative senescence downregulated leo1 like antibody, RNA polymerase associated protein LEO1 antibody, RNA polymerase-associated protein LEO1 antibody, Senescence downregulated leo1 like antibody
- UniProt
- Q8WVC0
- 途径
- Stem Cell Maintenance
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