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PRKACA 抗体 (pThr197)

This anti-PRKACA antibody is a 兔 多克隆 antibody detecting PRKACA in WB, ELISA, IHC 和 IF. Suitable for 人.
产品编号 ABIN7138793
发货至: 中国

Quick Overview for PRKACA 抗体 (pThr197) (ABIN7138793)

抗原

See all PRKACA 抗体
PRKACA (Protein Kinase A, alpha (PRKACA))

适用

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宿主

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克隆类型

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多克隆

标记

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This PRKACA antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 抗原表位

    • 15
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    pThr197

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

    免疫原

    Peptide sequence around phosphorylation site of threonine 197(R-T-W(p)-T-L) derived from Human PKA alpha/beta CAT.

    亚型

    IgG
  • 应用备注

    WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C,-80 °C

    储存方法

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原

    PRKACA (Protein Kinase A, alpha (PRKACA))

    别名

    PRKACA

    背景

    Background: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Ghislaine Garrel, Endocrinology, Jun 1997, 138: 2259. W Li, Learn. Mem., Jan 1996, 2: 320 - 333. Sharmin Schauble, J. Biol. Chem., May 2007, 282: 14952 - 14959. Yong G. Wang, J. Gen. Physiol., Jan 1998, 111: 113.

    Aliases: cAMP dependent protein kinase alpha catalytic subunit antibody, cAMP dependent protein kinase beta catalytic subunit antibody, cAMP dependent protein kinase catalytic beta subunit isoform 4ab antibody, cAMP dependent protein kinase catalytic subunit alpha antibody, cAMP dependent protein kinase catalytic subunit alpha, isoform 1 antibody, cAMP dependent protein kinase catalytic subunit beta antibody, cAMP-dependent protein kinase catalytic subunit alpha antibody, KAPCA_HUMAN antibody, PKA C alpha antibody, PKA C beta antibody, PKA C-alpha antibody, PKACA antibody, PKACB antibody, PPNAD4 antibody, PRKACA antibody, PRKACAA antibody, PRKACB antibody, Protein kinase A catalytic subunit alpha antibody, Protein kinase A catalytic subunit antibody, Protein kinase A catalytic subunit beta antibody, Protein kinase, cAMP dependent, catalytic, alpha antibody, Protein kinase, cAMP dependent, catalytic, beta antibody

    UniProt

    P17612

    途径

    NF-kappaB Signaling, Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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