YAP1 抗体 (pSer127)
Quick Overview for YAP1 抗体 (pSer127) (ABIN7138743)
抗原
See all YAP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer127
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of serine127(A-H-S(p)-S-P) derived from Human YAP .
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亚型
- IgG
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anti-Yes-Associated Protein 1 (YAP1) (AA 53-161) antibody
YAP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 131-330) antibodyYAP1 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (C-Term) antibodyYAP1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 绵羊, Cow, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 53-162) antibodyYAP1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) antibodyYAP1 适用: 人 WB, FACS, IHC (p), EIA 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Yes-Associated Protein 1 (YAP1) (pSer127) antibodyYAP1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Yes-Associated Protein 1 (YAP1) (AA 351-400) antibodyYAP1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 猴, 绵羊, 小鸡, Cow, 马, Pig, 兔, 非洲爪蟾, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB:1:500-1:1000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- YAP1 (Yes-Associated Protein 1 (YAP1))
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别名
- YAP1
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背景
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Background:
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.
Sorrentino G, et al. (2014) Nat Cell Biol 16, 357-66
Yang S, et al. (2014) Cell Signal 26, 343-51
Sun W, et al. (2014) Mol Biol Rep 41, 947-56Aliases: 65 kDa Yes associated protein antibody, 65 kDa Yes-associated protein antibody, COB1 antibody, YAp 1 antibody, YAP 65 antibody, YAP antibody, YAP-1 antibody, YAP1 antibody, YAP1_HUMAN antibody, YAP2 antibody, YAP65 antibody, yes -associated protein delta antibody, Yes associated protein 1 65 kDa antibody, Yes associated protein 1 antibody, Yes associated protein 2 antibody, yes associated protein beta antibody, YKI antibody, Yorkie homolog antibody
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UniProt
- P46937
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途径
- MAPK Pathway, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
抗原
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