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Recombinant FGFR4 抗体

FGFR4 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 8A5 unconjugated Recombinant Antibody
产品编号 ABIN7127491
发货至: 中国
  • 抗原 See all FGFR4 抗体
    FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
    抗体类型
    Recombinant Antibody
    适用
    • 88
    • 37
    • 26
    • 1
    • 1
    宿主
    • 72
    • 18
    • 2
    • 1
    克隆类型
    • 66
    • 24
    • 2
    单克隆
    标记
    • 50
    • 8
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    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This FGFR4 antibody is un-conjugated
    应用范围
    • 53
    • 40
    • 23
    • 22
    • 13
    • 13
    • 12
    • 11
    • 7
    • 6
    • 3
    • 2
    • 1
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    • 1
    ELISA, Immunohistochemistry (IHC)
    交叉反应
    纯化方法
    Affinity-chromatography
    免疫原
    A synthesized peptide derived from human FGFR4
    克隆位点
    8A5
    亚型
    IgG
    Top Product
    Discover our top product FGFR4 Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))
    别名
    FGFR4 (FGFR4 产品)
    背景

    Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

    Aliases: Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334), FGFR4, JTK2 TKF

    UniProt
    P22455
    途径
    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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