ZC3H12A 抗体
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- 抗原 See all ZC3H12A 抗体
- ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZC3H12A antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- zinc finger CCCH-type containing 12A
- 亚型
- IgG
- Top Product
- Discover our top product ZC3H12A Primary Antibody
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anti-Zinc Finger CCCH-Type Containing 12A (ZC3H12A) antibody
KO Validated ZC3H12A 适用: 人 WB, IHC, FACS, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger CCCH-Type Containing 12A (ZC3H12A) (AA 331-358) antibodyZC3H12A 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger CCCH-Type Containing 12A (ZC3H12A) (AA 331-358), (Middle Region) antibodyZC3H12A 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger CCCH-Type Containing 12A (ZC3H12A) (AA 1-260) antibodyZC3H12A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger CCCH-Type Containing 12A (ZC3H12A) (AA 320-369) antibodyZC3H12A 适用: 人, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger CCCH-Type Containing 12A (ZC3H12A) (AA 1-140) antibodyZC3H12A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:200-1:1000, IHC: 1:20-1:200, IP: 1:200-1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))
- 别名
- ZC3H12A (ZC3H12A 产品)
- 别名
- CGA antibody, MCPIP antibody, MCPIP1 antibody, RP3-423B22.1 antibody, dJ423B22.1 antibody, BC036563 antibody, Mcpip1 antibody, RGD1306776 antibody, chromogranin A antibody, zinc finger CCCH-type containing 12A antibody, zinc finger CCCH type containing 12A antibody, CHGA antibody, ZC3H12A antibody, Zc3h12a antibody
- 背景
- Synonyms:DJ423B22.1, FLJ23231, MCP induced protein 1, MCPIP, MCPIP1, Ribonuclease ZC3H12A, RP3 423B22.1, ZC3H12A Background:Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay(PubMed:19909337). Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation(PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines(IL6 and IL2), cell surface receptors(ICOS, TNFRSF4 and TNFR2) and transcription factor(REL)(By similarity). Self regulates by destabilizing its own mRNA(By similarity). Cleaves mRNA harboring a stem-loop(SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner(PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs(miRNAs) biogenesis(PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs(pre-miRNAs) important for the regulation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs(PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity(PubMed:24048733). Affects the overall ubiquitination of cellular proteins(By similarity). Positively regulates deubiquitinase activity promoting the cleavage at 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains on TNF receptor-associated factors(TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regulating macrophage-mediated inflammatory response and immune homeostasis(By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regulating the expression of proangiogenic HIF1A-targeted genes(PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage(PubMed:25861989). Prevents stress granule(SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation(By similarity). Plays a role in the regulation of macrophage polarization, promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state(By similarity). May also act as a transcription factor that regulates the expression of multiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis(PubMed:16574901, PubMed:18364357). Functions as a positive regulator of glial differentiation of neuroprogenitor cells through an amyloid precursor protein(APP)-dependent signaling pathway(PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide(LPS) by reducing I-kappa-B-kinase(IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production(By similarity). (Microbial infection) Exhibits broad antiviral activity by cleaving viral RNAs(PubMed:23355615). Binds to Japanese encephalitis virus(JEV) and dengue virus(DEN) RNAs(PubMed:23355615). Exhibits antiviral activity against HIV-1 in lymphocytes by decreasing the abundance of HIV-1 viral RNA species(PubMed:24191027).
- 分子量
- 66 kDa
- 基因ID
- 80149
- UniProt
- Q5D1E8
- 途径
- Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation
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