Ubiquilin 2 抗体
Quick Overview for Ubiquilin 2 抗体 (ABIN7120457)
抗原
See all Ubiquilin 2 (UBQLN2) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- UBQLN2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- ubiquilin 2
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亚型
- IgG
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anti-Ubiquilin 2 (UBQLN2) (AA 555-624) antibody
UBQLN2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5F5 unconjugated
anti-Ubiquilin 2 (UBQLN2) (AA 1-150) antibodyUBQLN2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) (AA 473-542) antibodyUBQLN2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) antibodyUBQLN2 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) (AA 33-126) antibodyUBQLN2 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) antibodyUBQLN2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) (AA 555-624) antibodyUBQLN2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) (C-Term) antibodyUBQLN2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) (AA 81-130) antibodyUBQLN2 适用: 人, 大鼠, Cow, 犬, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquilin 2 (UBQLN2) (N-Term) antibodyUBQLN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:200-1:2000, IHC: 1:20-1:200,IF:1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- Ubiquilin 2 (UBQLN2)
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别名
- UBQLN2
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背景
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Synonyms: Ubiquilin-2|Chap1|DSK2 homolog|Protein linking IAP with cytoskeleton 2 (PLIC-2, hPLIC-2)|Ubiquitin-like product Chap1/Dsk2|UBQLN2|N4BP4|PLIC2
Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system(UPS), autophagy and the endoplasmic reticulum-associated protein degradation(ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding(via UBA domain) to their polyubiquitin chains and by interacting(via ubiquitin-like domain) with the subunits of the proteasome(PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome(PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion(PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits(CCPs)(PubMed:18199683).
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分子量
- 70 kDa
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基因ID
- 29978
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UniProt
- Q9UHD9
抗原
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