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Ubiquilin 2 抗体 (AA 473-542)

UBQLN2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7174228
发货至: 中国
  • 抗原 See all Ubiquilin 2 (UBQLN2) 抗体
    Ubiquilin 2 (UBQLN2)
    抗原表位
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 473-542
    适用
    • 49
    • 12
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 44
    • 5
    克隆类型
    • 45
    • 4
    多克隆
    标记
    • 23
    • 5
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Ubiquilin 2 antibody is un-conjugated
    应用范围
    • 31
    • 23
    • 15
    • 9
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    交叉反应
    纯化方法
    >95%, Protein G purified
    免疫原
    Recombinant Human Ubiquilin-2 protein (473-542AA)
    亚型
    IgG
    Top Product
    Discover our top product UBQLN2 Primary Antibody
  • 应用备注
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 抗原
    Ubiquilin 2 (UBQLN2)
    别名
    UBQLN2 (UBQLN2 产品)
    别名
    ALS15 antibody, CHAP1 antibody, DSK2 antibody, N4BP4 antibody, PLIC2 antibody, Chap1 antibody, Dsk2 antibody, HRIHFB2157 antibody, Plic-2 antibody, Plic2 antibody, RGD1563566 antibody, UBQLN2 antibody, ubiquilin 2 antibody, UBQLN2 antibody, Ubqln2 antibody
    背景

    Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).

    Aliases: UBQLN2 antibody, N4BP4 antibody, PLIC2 antibody, HRIHFB2157Ubiquilin-2 antibody, Chap1 antibody, DSK2 homolog antibody, Protein linking IAP with cytoskeleton 2 antibody, PLIC-2 antibody, hPLIC-2 antibody, Ubiquitin-like product Chap1/Dsk2 antibody

    UniProt
    Q9UHD9
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