FAS 抗体 (AA 156-335)
Quick Overview for FAS 抗体 (AA 156-335) (ABIN7119981)
抗原
See all FAS 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 156-335
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原理
- FAS antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 156-335aa
Immunogen: Fas(TNF receptor superfamily, member 6)
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亚型
- IgG2a
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应用备注
- WB: 1:1000-1:8000, IHC: 1:50-1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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别名
- FAS
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背景
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Synonyms: Tumor necrosis factor receptor superfamily member 6|Apo-1 antigen|Apoptosis-mediating surface antigen FAS|FASLG receptor|FAS|APT1|FAS1|TNFRSF6
Background: Fas(CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.
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分子量
- 38-45 kDa
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基因ID
- 355
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UniProt
- P25445
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途径
- p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
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