ITK 抗体
Quick Overview for ITK 抗体 (ABIN7115182)
抗原
See all ITK 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ITK antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- IL2-inducible T-cell kinase
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亚型
- IgG
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anti-IL2-Inducible T-Cell Kinase (ITK) (Internal Region) antibody
Verified ITK 适用: 人, 大鼠 WB, ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5G6 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (C-Term) antibodyVerified ITK 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 2-110) antibodyITK 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5G12C4 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (pTyr512) antibodyITK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 368-625) antibodyITK 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 8F10 unconjugated Recombinant Antibody
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 228-262) antibodyITK 适用: 人 WB 宿主: 兔 Polyclonal RB50773 unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) (AA 1-111) antibodyITK 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-IL2-Inducible T-Cell Kinase (ITK) antibodyITK 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ITK (IL2-Inducible T-Cell Kinase (ITK))
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别名
- ITK
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背景
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Synonyms: Tyrosine-protein kinase ITK/TSK|Interleukin-2-inducible T-cell kinase (IL-2-inducible T-cell kinase)|Kinase EMT|T-cell-specific kinase|Tyrosine-protein kinase Lyk|ITK|EMT|LYK
Background: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells(APC) activate T-cell receptor(TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells(NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.
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分子量
- 68-72 kDa
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基因ID
- 3702
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UniProt
- Q08881
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
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